4-[(4,5-Dihydro-2-thiazolyl)amino]tetrahydro-3,5-bis[(4-methoxyphenyl)methylene]thiopyran-4-ol-1,1-dioxide → 2,3,8,9-Tetrahydro-5-(4-methoxyphenyl)-9-[(4-methoxyphenyl)methylene]-5H,6H-thiazolo[3,2-a]thiopyrano[4,3-d]pyrimidine-7,7-dioxide
반응식
[S:1]1[CH2:5][CH2:4][N:3]=[C:2]1[NH:6][C:7]1(O)[C:12](=[CH:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[CH2:11][S:10](=[O:23])(=[O:22])[CH2:9][C:8]1=[CH:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=1>CCCCO.CS(C)=O>[CH3:32][O:31][C:28]1[CH:29]=[CH:30][C:25]([CH:24]2[N:3]3[CH2:4][CH2:5][S:1][C:2]3=[N:6][C:7]3[C:12](=[CH:13][C:14]4[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=4)[CH2:11][S:10](=[O:22])(=[O:23])[CH2:9][C:8]2=3)=[CH:26][CH:27]=1참가 물질
4
반응물 1
생성물 1
시약·촉매·용매 2
실험 절차
A suspension of 4-[(4,5-dihydro-2-thiazolyl)amino]-tetrahydro-3,5-bis[(4-methoxyphenyl)methylene]thiopyran-4-ol-1,1-dioxide (6.0 g, 0.012 mole) in 75 ml of n-BuOH and 25 ml of DMSO is stirred and heated at reflux for 1 hour. The volume of the resulting solution is reduced by approximately one-half using a Dean-Stark trap. After cooling, the yield of yellow product is 4.7 g, m.p. 235°-240°. Crystallization from 25 ml of DMF gives 4.0 g (69%) of cream colored product, m.p. 243°-245°.