Bromine → 5-Bromo-2-methoxybenzonitrile

HRID 657334

반응식

HRID 657334 반응식
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8]>C(Cl)(Cl)Cl>[Br:1][C:10]1[CH:11]=[CH:12][C:5]([O:4][CH3:3])=[C:6]([CH:9]=1)[C:7]#[N:8]

참가 물질

4

반응물 2

HCID 24408BromineHCID 810862-Methoxybenzonitrile

생성물 1

HCID 44185605-Bromo-2-methoxybenzonitrile수율 71.4%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

Bromine (13.7 g, 86.0 mmol) in CHCl3 (20 mL) was added to a solution of 2-(methyloxy)benzonitrile (10.9 g, 81.9 mmol) in CHCl3 (50 mL). The mixture was refluxed for 29 h. The reaction was allowed to cool to room temperature, and washed with saturated sodium bisulfite (50 mL), and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate. Evaporation of the solvent afforded 5-bromo-2-(methyloxy)benzonitrile (12.4 g, 71%).

후처리

  1. temperatureThe mixture was refluxed for 29 h
  2. washwashed with saturated sodium bisulfite (50 mL), and brine (50 mL)
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-91481a9d681b44488b6800dcaf7e00da
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071588B2

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