Water → 2-Bromo-6-methylanisole

HRID 657336노트

반응식

HRID 657336 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[OH:9].[H-].[Na+].[CH3:12]OS(OC)(=O)=O.O>C1COCC1>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[O:9][CH3:12]

참가 물질

6

반응물 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 24758Sodium hydrideHCID 110953292-Bromo-6-methylphenol

생성물 1

HCID 122626482-Bromo-6-methylanisole수율 97.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-bromo-6-methylphenol (34.6 g, 0.18 mol) in THF (300 mL) was added NaH (9.6 g, 0.24 mol, 60%) in several portions. After the mixture was stirred for 1 h, Me2SO4 (28.0 g, 0.22 mol) was added dropwise. Then the mixture was stirred over night. Water (50 mL) was added, and the solvent was removed under reduced pressure. Then the residue was dissolved in Et2O (250 mL) and the organic layer was washed with NaOH (5%, 100 mL), brine (100 mL), and dried with Na2SO4. After removing the solvent, 35.3 g of the crude product was obtained (yield: 95%). 1H NMR (400 MHz, CDCl3) δ 2.33 (s, 3H), 3.81 (s, 3H), 6.88 (t, J=8.0 Hz, 1H), 7.10 (d, J=8.0 Hz, 1H), 7.30 (d, J=7.6 Hz, 1H).

후처리

  1. stirringThen the mixture was stirred over night
  2. customthe solvent was removed under reduced pressure
  3. dissolutionThen the residue was dissolved in Et2O (250 mL)
  4. washthe organic layer was washed with NaOH (5%, 100 mL), brine (100 mL)
  5. dry with materialdried with Na2SO4
  6. customAfter removing the solvent

출처 및 근거

ORD 기록
ord-12f394a7d72b46e2932be950cc2b50d3
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071588B2

반응 노트

불러오는 중…