Triphenylphosphine → HCID 23150257, 화합물

HRID 657649

반응식

HRID 657649 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:24]([N:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[C:25]#[CH:26].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C([O-])(=O)C([O-])=O>C(N(CC)CC)C>[N:27]1([CH2:24][C:25]#[C:26][C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][N:18]4[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]4)=[CH:10][CH:9]=3)=[CH:4][CH:3]=2)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 71081OxalateHCID 3366521-(Prop-2-yn-1-yl)piperidineHCID 231503131-{3-[(4'-Bromobiphenyl-4-yl)oxy]propyl}piperidine

생성물 1

HCID 23150257HCID 23150257, 화합물수율 21.4%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

Following the procedure described in example 43§C, but starting from 1-{3-[(4′-bromobiphenyl-4-yl)oxy]propyl}piperidine (0.75 g), 1-prop-2-yn-1-ylpiperidine (320 mg), triethylamine (20 mL), cuprous iodide (4.2 mg), triphenylphosphine (20 mg) and bis(triphenylphosphinepalladiumdichloride) affords 179 mg of 1-(3-{[4′-(3-piperidinoprop-1-yn-1-yl)biphenyl-4-yl]oxy}propyl)piperidine which oxalate melts at 195° C.

출처 및 근거

ORD 기록
ord-8ac4ff95480b4bbaaaf4254bd7871ada
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076329B2

연결된 노트

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