Phosphorus oxybromide → 1-benzyl-4-bromo-5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]-pyridin-11(1H)one

HRID 65782

반응식

[CH2:1]([N:8]1[C:16]2[N:15]=[C:14]3[C:17](=[O:26])[C:18]4[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=4[CH2:20][CH2:21][C:13]3=[C:12](O)[C:11]=2[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Br)(Br)([Br:30])=O.P(Cl)(Cl)(Cl)=O>>[CH2:1]([N:8]1[C:16]2[N:15]=[C:14]3[C:17](=[O:26])[C:18]4[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=4[CH2:20][CH2:21][C:13]3=[C:12]([Br:30])[C:11]=2[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 24613Phosphorus oxybromide

HCID 24813Phosphorus oxychloride

HCID 178514946HCID 178514946, 화합물

생성물 1

HCID 227577601-benzyl-4-bromo-5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]-pyridin-11(1H)one

실험 절차

By treating the product of Example 10 according to the procedure of Example 2, but substituting phosphorus oxybromide for the phosphorus oxychloride, 1-benzyl-4-bromo-5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)one is obtained.

출처 및 근거

ORD 기록: ord-718f89131b9946e48179fab1305fef8b
출처 데이터셋: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04128717

연결된 노트

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