Catechol → o-(1-Methoxyethoxy)-phenol

HRID 65899

반응식

HRID 65899 반응식
[C:1]1([C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4])[OH:2].[CH:9]([O:11][CH3:12])=[CH2:10].Cl.[OH-].[Na+]>C1(C)C=CC=CC=1>[CH3:12][O:11][CH:9]([O:2][C:1]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[OH:4])[CH3:10]

참가 물질

6

반응물 4

HCID 289CatecholHCID 313Hydrochloric AcidHCID 7861Methyl vinyl etherHCID 14798Sodium Hydroxide

생성물 1

HCID 20431181o-(1-Methoxyethoxy)-phenol

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

110 parts by weight of pyrocatechol is suspended in 100 parts by weight of toluene. At +5° C., 64 parts by weight of vinylmethyl ether at -40° C. is introduced all at once into the suspension and a drop of concentrated hydrochloric acid is then added. The mixture is heated, with stirring, to about +20° C., whereupon the reaction is initiated and the temperature in the flask rises to about 65° C. If necessary, ice water may be used for external cooling. The mixture is kept for 30 minutes at 65° C. and 5 parts by weight of 2N NaOH is then added. After the mixture has been cooled and dried with Na2SO4 the solvent is evaporated in a rotary evaporator and distillation carried out in vacuo.

후처리

  1. temperatureThe mixture is heated
  2. customrises to about 65° C
  3. temperatureAfter the mixture has been cooled
  4. dry with materialdried with Na2SO4 the solvent
  5. customis evaporated in a rotary evaporator and distillation

출처 및 근거

ORD 기록
ord-0642839368094bf1b705146b7cff2353
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129601

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