Diisopropylethylamine → 3-{3-[(5-Phenoxy-furan-2-carbonyl)-amino]-phenyl}-acrylic acid

HRID 659095

반응식

HRID 659095 반응식
[O:1]([C:8]1[O:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:18][C:19](=[O:29])[CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([NH2:28])[CH:23]=1)C.CCN(C(C)C)C(C)C>CN(C=O)C>[O:1]([C:8]1[O:12][C:11]([C:13]([NH:28][C:24]2[CH:23]=[C:22]([CH:21]=[CH:20][C:19]([OH:29])=[O:18])[CH:27]=[CH:26][CH:25]=2)=[O:15])=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 978253-Aminocinnamic acid ethyl esterHCID 28127905-Phenoxyfuran-2-carboxylic acid

생성물 1

HCID 684136603-{3-[(5-Phenoxy-furan-2-carbonyl)-amino]-phenyl}-acrylic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5-phenoxy-2-furoic acid (3) (213 mg, 1.05 mmol) was coupled to aniline (2) (200 mg, 1.05 mmol) using Method B, except that DIPEA (270 mg, 2.09 mmol) and DMF (2 mL) were used to give the title compound. Yield: 178 mg, 96%; LC/MS tr 1.65 min; HPLC Purity: 95%; MS (ES+) m/z 378 (M+H)

출처 및 근거

ORD 기록
ord-b572637309d44c8aa5c4bf03177b49eb
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080567B2

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