Methanol → 3-[3-(5-Phenyl-benzoxazol-2-yl)-phenyl]-acrylic acid

HRID 659113

반응식

HRID 659113 반응식
C[O:2][C:3](=[O:27])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[CH:17][C:15]=3[N:16]=2)[CH:7]=1.CO.[OH-].[Na+]>C1COCC1>[C:21]1([C:18]2[CH:19]=[CH:20][C:14]3[O:13][C:12]([C:8]4[CH:7]=[C:6]([CH:5]=[CH:4][C:3]([OH:27])=[O:2])[CH:11]=[CH:10][CH:9]=4)=[N:16][C:15]=3[CH:17]=2)[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 684169753-[3-(5-Phenyl-benzoxazol-2-yl)-phenyl]-acrylic acid methyl ester

생성물 1

HCID 684142043-[3-(5-Phenyl-benzoxazol-2-yl)-phenyl]-acrylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The ester (33) (41 mg, 0.12 mmol) was hydrolysed using Method C, except that MeOH (3 mL), THF (3 mL) and 1M NaOH (5 mL) were used, and the reaction was stirred for 2 hours. Yield: 21 mg, 53%; LC-MS tr 1.74 min; HPLC Purity: 96%; MS (ES+) m/z 342 (M+H); 1H NMR (400 MHz; DMSO): δ 6.7 (d, 1H), 7.4 (t, 1H), 7.45-7.55 (t, 2H), 7.70-7.80 (m, 5H), 7.9 (d, 1H), 8.05 (d, 1H), 8.10 (s, 1H), 8.30 (d, 1H), 8.50 (s, 1H), 12.55 (br. s, 1H)

후처리

  1. waitLC-MS tr 1.74 min

출처 및 근거

ORD 기록
ord-1cbcba417ca24b8fb7e52db701996fee
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080567B2

연결된 노트

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