Diethyl Ether → 7-Chloro-1-methyllepidinium iodide

HRID 6602

반응식

HRID 6602 반응식
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.C[I:14].[CH2:15](OCC)C>CC#N>[I-:14].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][CH:8]=[N+:9]2[CH3:15])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 1704377-Chloro-4-methylquinoline

생성물 1

HCID 220163717-Chloro-1-methyllepidinium iodide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A portion of the 7-chlorolepidine (80 mg) prepared as above was methylated by heating with CH3I (0.5 ml) in CH3CN (1 ml) at reflux for two hours. The mixture was treated with diethyl ether, followed by centrifugation, to give a yellow powder.

후처리

  1. temperatureat reflux for two hours
  2. customto give a yellow powder

출처 및 근거

ORD 기록
ord-6a873647e2b44ce99055068705e47796
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07083982B2

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