Bromine → 5-Bromo-2-methoxybenzonitrile

HRID 662036

반응식

HRID 662036 반응식
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8]>C(Cl)(Cl)Cl>[Br:1][C:10]1[CH:11]=[CH:12][C:5]([O:4][CH3:3])=[C:6]([CH:9]=1)[C:7]#[N:8]

참가 물질

4

반응물 2

HCID 24408BromineHCID 810862-Methoxybenzonitrile

생성물 1

HCID 44185605-Bromo-2-methoxybenzonitrile수율 71.4%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

Br2 (13.7 g, 86.0 mmol) in CHCl3 (20 mL) was added to a solution of 2-(methyloxy)benzonitrile (10.9 g, 81.9 mmol) in CHCl3 (50 mL). The mixture was refluxed for 29 h. The reaction was allowed to cool to room temperature, and washed with saturated sodium bisulfite (50 mL), and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate. Evaporation of the solvent afforded 5-bromo-2-(methyloxy)benzonitrile (12.4 g, 71%).

후처리

  1. temperatureThe mixture was refluxed for 29 h
  2. washwashed with saturated sodium bisulfite (50 mL), and brine (50 mL)
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-ee9078e3cb3d4d9ca94b6bdff0d821a7
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084449B2

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