Propylenediamine → 1-Methyl-2-(3-phenylureido)ethylamine

반응식

[C:1]1([NH:7][C:8](=[O:12])OCC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:13][CH2:14][CH:15]([NH2:17])[CH3:16]>>[CH3:16][CH:15]([NH2:17])[CH2:14][NH:13][C:8]([NH:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:12]

참가 물질

반응물 2

HCID 6567Propylenediamine

HCID 7591Ethyl N-phenylcarbamate

생성물 1

HCID 536666351-Methyl-2-(3-phenylureido)ethylamine

반응 조건

온도: 125 °C

실험 절차

A mixture of ethyl phenylcarbamate (50 g.) and 1,2-diaminopropane (105 g.) is heated at 125° C. for 17 hours and cooled, and the excess of amine is removed by evaporation under reduced pressure. The residue is dissolved in ethyl acetate and the solution is washed with saturated brine, dried and evaporated to dryness. The residue is triturated with toluene and there is thus obtained as solid residue 1-methyl-2-(3-phenylureido)ethylamine, which is used without further purification.

후처리

temperaturecooled
customthe excess of amine is removed by evaporation under reduced pressure
dissolutionThe residue is dissolved in ethyl acetate
washthe solution is washed with saturated brine
customdried
customevaporated to dryness
customThe residue is triturated with toluene and there

출처 및 근거

ORD 기록: ord-129ebabf9e89424b8767af64051836c2
출처 데이터셋: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04131685

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