Sulfuric Acid → Oxazolo[4,5-b]pyridin-2-yl(phenyl)methanone

HRID 66352노트

반응식

HRID 66352 반응식
[CH2:1]([C:8]1[O:9][C:10]2[C:11]([N:16]=1)=[N:12][CH:13]=[CH:14][CH:15]=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Mn]([O-])(=O)(=O)=[O:18].[K+].S(=O)(=O)(O)O.S(=O)(O)[O-].[Na+]>[OH-].[Na+].O>[C:1]([C:8]1[O:9][C:10]2[C:11]([N:16]=1)=[N:12][CH:13]=[CH:14][CH:15]=2)(=[O:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

7

반응물 4

HCID 1118Sulfuric AcidHCID 516875Potassium PermanganateHCID 227548052-Benzyloxazolo[4,5-b]pyridineHCID 23665763Sodium Bisulfite

생성물 1

HCID 22754809Oxazolo[4,5-b]pyridin-2-yl(phenyl)methanone

시약·촉매·용매 2

HCID 14798Sodium Hydroxide촉매HCID 962Water용매

실험 절차

A mixture of 800 mg. of 2-benzyloxazolo[4,5-b]pyridine, 2.5 g. of potassium permanganate, 35 ml. of water and 6 drops of 2.5 N sodium hydroxide solution was heated at 50°-55° C. for 3 hours. After cooling, sulfuric acid was added to about pH 6 and sufficient sodium bisulfite was added to remove the manganese dioxide. The crystalline precipitate remaining was collected and recrystallized from ethylacetate to give 2-benzoyloxazolo[4,5-b]pyridine, m.p. 151°-153° C.

후처리

  1. additionA mixture of 800 mg
  2. temperatureAfter cooling
  3. additionwas added
  4. customto remove the manganese dioxide
  5. customThe crystalline precipitate remaining was collected
  6. customrecrystallized from ethylacetate

출처 및 근거

ORD 기록
ord-c32ca1f760c7496791ecdcdf0b8c4ce7
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131677

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