Phenyl Isothiocyanate → N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea

HRID 66562

반응식

HRID 66562 반응식
C(N(CC)CC)C.Br.[CH3:9][N:10]1[CH2:14][CH2:13][N:12]([CH3:15])[C:11]1=[NH:16].[C:17]1([N:23]=[C:24]=[S:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(Cl)(Cl)Cl>[CH3:9][N:10]1[CH2:14][CH2:13][N:12]([CH3:15])[C:11]1=[N:16][C:24]([NH:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[S:25]

참가 물질

5

반응물 3

HCID 7673Phenyl IsothiocyanateHCID 8471TriethylamineHCID 134927221,3-Dimethyl-2-imino-imidazolidine hydrobromide

생성물 1

HCID 20530303N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

30.4 g (0.3 mol) of triethylamine are added to a suspension of 58.2 g (0.3 mol) of 1,3-dimethyl-2-imino-imidazolidine hydrobromide in 470 ml of chloroform, at 5°, with stirring. A solution of 40.6 g (0.3 mol) of phenyl isothiocyanate in 235 ml of chloroform is then added dropwise and the reaction mixture is refluxed for 15 hours. After cooling, it is washed with water, dried over sodium sulfate and evaporated in vacuo. Crude N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea is obtained and after recrystallisation from ethanol this melts at 195°-196°.

후처리

  1. temperaturethe reaction mixture is refluxed for 15 hours
  2. temperatureAfter cooling
  3. washit is washed with water
  4. dry with materialdried over sodium sulfate
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-3610284790264e4e93319b0dd2f35d2c
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04342764

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