Dimethyl Sulfoxide → 2-(4-Chlorophenoxy)acetonitrile

HRID 66728

반응식

HRID 66728 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:16][C:17]#[N:18].CS(C)=O>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:16][C:17]#[N:18])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 46844-ChlorophenolHCID 7856ChloroacetonitrileHCID 11430Potassium Carbonate

생성물 1

HCID 3064442-(4-Chlorophenoxy)acetonitrile수율 92.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 64.25 g of 4-chlorophenol, 98 g of anhydrous potassium carbonate, 40 g of chloroacetonitrile and 100 ml of dimethyl sulfoxide was heated with stirring in a 500 ml round-bottomed three-necked flask at 70°-80° C. for 3.0 hours. The reaction mixture was then poured into ice and water. After the ice melted, the mixture was filtered and the product washed well with water which gave 77.5 g of 4-chlorophenoxyacetonitrile.

후처리

  1. temperaturewas heated
  2. filtrationthe mixture was filtered
  3. washthe product washed well with water which

출처 및 근거

ORD 기록
ord-9c18c5a5f562428fb1f2d2a6984cc88c
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343809

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