Hydrochloric Acid → 8-Methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylic Acid

HRID 66776노트

반응식

HRID 66776 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][C:9]([C:13]([O:15]CC)=[O:14])=[C:8]2[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH3:25].[OH-].[Na+].C(O)C.Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][C:9]([C:13]([OH:15])=[O:14])=[C:8]2[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH3:25]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 130384398-Methoxy-4-o-tolylamino-quinoline-3-carboxylic acid ethyl ester

생성물 1

HCID 130384408-Methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylic Acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of Ethyl 8-methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylate, 15.00 g (0.0445 mole), 100 ml of 3 N sodium hydroxide solution and 100 ml of ethanol was stirred at room temperature for 16 hours. The mixture was diluted with 300 ml of water and acidified to pH 6.8 with 6 N hydrochloric acid solution. The precipitate was collected by filtration, washed in succession with water and acetone and air dried for about 1.5 hr. Weight of solid was 13.41 g (98%), m.p. 272° C. (d).

후처리

  1. filtrationThe precipitate was collected by filtration
  2. washwashed in succession with water and acetone and air
  3. customdried for about 1.5 hr

출처 및 근거

ORD 기록
ord-01be616c14cc409ba37998d98552c46b
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343804

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