Chloroform → N-(7-ethoxy-1,3,4,9-tetrahydro-2H-carbazol-2-yl)acetamide

HRID 66789노트

반응식

HRID 66789 반응식
[OH:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH2:7][CH2:8][CH:9]([NH:15][C:16](=[O:18])[CH3:17])[CH2:10][C:11]=3[NH:12]2)=[CH:4][CH:3]=1.[CH2:19](I)[CH3:20].C([O-])([O-])=O.[K+].[K+].C(Cl)(Cl)Cl>O>[CH2:19]([O:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH2:7][CH2:8][CH:9]([NH:15][C:16](=[O:18])[CH3:17])[CH2:10][C:11]=3[NH:12]2)=[CH:4][CH:3]=1)[CH3:20]

참가 물질

6

반응물 4

HCID 6212ChloroformHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 20529233N-(1,3,4,9-tetrahydro-7-hydroxy-2H-carbazol-2-yl)acetamide

생성물 1

HCID 20529245N-(7-ethoxy-1,3,4,9-tetrahydro-2H-carbazol-2-yl)acetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 0.02 mol of N-(1,3,4,9-tetrahydro-7-hydroxy-2H-carbazol-2-yl)acetamide, 0.022 mol of ethyl iodide, 0.022 mol of anhydrous K2CO3, and 50 ml of Me2CO was stirred and refluxed for 48 hr. Sufficient CHCl3 and H2O were added to the cooled reaction mixture to give two clear layers. The CHCl3 layer was washed with 1 N NaOH, H2O, dried, evaporated, and the resulting solid residue was recrystallized from i-PrOH to give the title compound, mp 184°-186°.

후처리

  1. temperaturerefluxed for 48 hr
  2. customto give two clear layers
  3. washThe CHCl3 layer was washed with 1 N NaOH, H2O
  4. customdried
  5. customevaporated
  6. customthe resulting solid residue was recrystallized from i-PrOH

출처 및 근거

ORD 기록
ord-50f1e3129a504327ab190b0c9078daf3
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343812

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