Methyl iodide → HCID 20529171, 화합물

HRID 66821

반응식

HRID 66821 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]([CH3:18])=[C:12]2[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[CH3:28]I>CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:28])[C:13]([CH3:18])=[C:12]2[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 205292015-Benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole

생성물 1

HCID 20529171HCID 20529171, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

An amount of 3.21 g (9.25 m mole) of 5-benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole was dissolved in 50 ml of absolute dimethylformamide, and the solution was mixed with 406 mg (9.3 m mole) of 55% sodium hydride in paraffin oil. After one hour 1.45 g (10.2 m mole) of methyliodide were added, and the mixture was stirred overnight. After evaporation, the reaction mixture was mixed with water and extracted with chloroform. The extracts, which were dried over sodium sulfate, were evaporated, and the residue obtained was purified by chromatography on silicagel by using toluene as solvent.

후처리

  1. customAfter evaporation
  2. additionthe reaction mixture was mixed with water
  3. extractionextracted with chloroform
  4. dry with materialThe extracts, which were dried over sodium sulfate
  5. customwere evaporated
  6. customthe residue obtained
  7. customwas purified by chromatography on silicagel

출처 및 근거

ORD 기록
ord-9be5438826f3452d949f2a84691685a7
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343811

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