Sodium Hydroxide → HCID 3059434, 화합물

HRID 66908노트

반응식

HRID 66908 반응식
[CH3:1][C:2]([O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:16][CH2:17][CH3:18])[C:11]([CH3:19])=[C:10]2[C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)([CH3:5])[CH2:3][OH:4].[OH-].[Na+].[Mn]([O-])(=O)(=O)=[O:29].[K+]>O1CCOCC1.O>[CH3:1][C:2]([O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:16][CH2:17][CH3:18])[C:11]([CH3:19])=[C:10]2[C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)([CH3:5])[C:3]([OH:29])=[O:4]

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 516875Potassium PermanganateHCID 20529122HCID 20529122, 화합물

생성물 1

HCID 3059434HCID 3059434, 화합물

시약·촉매·용매 2

HCID 962Water용매2회HCID 312751,4-Dioxane용매

실험 절차

An amount of 3.38 g (10 m mole) of 2-methyl-2-[2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-5-yloxy]propanol in 50 ml of dioxane was successively mixed with 300 mg of sodium hydroxide in 5 ml of water and then with 3.4 g of potassium permanganate dissolved in 30 ml of water. After stirring for 12 hours, the reaction mixture was filtered, evaporated, and neutralized with dilute sulfuric acid. After extraction with chloroform, the organic phase was dried over sodium sulfate and evaporated. The evaporation residue was recrystallized from ethanol.

후처리

  1. filtrationthe reaction mixture was filtered
  2. customevaporated
  3. extractionAfter extraction with chloroform
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. customevaporated
  6. customThe evaporation residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-47e4be5935044b9eb9e6ff96489fdc5c
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343811

반응 노트

불러오는 중…