p-Anisoyl chloride → 5-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66938

반응식

HRID 66938 반응식
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[C:11](Cl)(=[O:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1>C1(C)C(C)=CC=CC=1>[C:11]([NH:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1)(=[O:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 7477p-Anisoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

생성물 1

HCID 130415175-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 12.8 g (0.08 mole) 4-anisoyl chloride in 200 ml xylene was heated at reflux for 20 hours. Cooling of the reaction mixture resulted in precipitation of the crude product, which was then isolated by filtration. Purification was achieved by washing the crude product with hot hexane. Yield was 12.0 g (82%); m.p. 172° C.

후처리

  1. temperatureat reflux for 20 hours
  2. temperatureCooling of the reaction mixture

출처 및 근거

ORD 기록
ord-c5e879964bea48bfb1cb9bbca35b987c
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343945

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