O-Cresol → 4-Chloro-2-methylphenol

반응식

S(Cl)([Cl:4])(=O)=O.[C:6]1([CH3:13])[C:11]([OH:12])=[CH:10][CH:9]=[CH:8][CH:7]=1>>[Cl:4][C:8]1[CH:7]=[C:6]([CH3:13])[C:11]([OH:12])=[CH:10][CH:9]=1

참가 물질

반응물 2

HCID 335O-Cresol2회

HCID 24648Sulfuryl chloride2회

생성물 1

HCID 148554-Chloro-2-methylphenol수율 84%

실험 절차

The chlorination of aromatic compounds with sulfuryl chloride is generally known. For example, DuBois in Z. F. Chem. 705 (1866) reported that treatment of molten phenol with an equal molar amount of sulfuryl chloride yields only p-chlorophenol. Sulfuryl chloride was first reported as a chlorinating agent for o-cresol by Sah and Anderson in J. Am. Chem. Soc. 63, 3164 (1941). Their data showed that o-cresol reacted with sulfuryl chloride to yield 84% of the 4-chloro-o-cresol.

출처 및 근거

ORD 기록: ord-6de4de661824448bb1353af245631ff8
출처 데이터셋: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04345097

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