Hydrochloric Acid → HCID 20528316, 화합물

HRID 67239

반응식

HRID 67239 반응식
C1C(C=O)=CC2OCOC=2C=1.FC1C=CC(C=O)=CC=1.[C-]#N.[K+].[F:24][C:25]1[CH:43]=[CH:42][C:28]([CH:29](O)[C:30](=[O:40])[C:31]2[CH:36]=[CH:35][C:34]3[O:37][CH2:38][O:39][C:33]=3[CH:32]=2)=[CH:27][CH:26]=1.C1(C(C(C2C=CC=CC=2)O)=O)C=CC=CC=1.[NH:60]1[CH2:66][CH2:65][CH2:64][CH2:63][NH:62][C:61]1=[S:67].[ClH:68]>CC(C)=O.C(O)C>[ClH:68].[F:24][C:25]1[CH:43]=[CH:42][C:28]([CH:29]2[S:67][C:61]3=[N:60][CH2:66][CH2:65][CH2:64][CH2:63][N:62]3[C:30]2([C:31]2[CH:36]=[CH:35][C:34]3[O:37][CH2:38][O:39][C:33]=3[CH:32]=2)[OH:40])=[CH:27][CH:26]=1

참가 물질

10

반응물 7

HCID 313Hydrochloric AcidHCID 8400BenzoinHCID 8438PiperonalHCID 9032Potassium CyanideHCID 680234-FluorobenzaldehydeHCID 7365891,3-Diazepane-2-thioneHCID 54204893HCID 54204893, 화합물

생성물 1

HCID 20528316HCID 20528316, 화합물

시약·촉매·용매 2

HCID 180Acetone용매HCID 702Ethanol용매

실험 절차

A mixture consisting of 12 g. of piperonal 8.4 ml. of p-fluorobenzaldehyde, 6 g. of potassium cyanide, and 80 ml. of 65% ethanol is reacted as described in Example 20, giving 11.7 g. of 4'-fluoro-3,4-methylenedioxybenzoin as an uncrystallizable oil. 9.0 g. of this benzoin is converted to its methanesulfonate ester by the procedure of Example 20, yielding 9.8 g. of ester as an uncrystallizable oil. The reaction of 4.9 g. of the crude methanesulfonate ester, and 1.16 g. of hexahydro-2H-1,3-diazepin-2-thione in 80 ml. of acetone, followed by treatment with 5 ml of 2 N ethanolic hydrogen chloride gives the title compound melting at 211°-213° C.

후처리

  1. customgiving 11.7 g
  2. customyielding 9.8 g
  3. customThe reaction of 4.9 g

출처 및 근거

ORD 기록
ord-ba8adce569ad490c9586f19986e695ad
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04344954

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