Lauric Acid → 4-lauramidoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

HRID 67666

반응식

HRID 67666 반응식
[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH2:7].[C:8]([O:14]C)(=O)[CH2:9][C:10]([CH3:12])=O.[C:16](O)(=[O:28])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]>>[C:16]([NH:1][CH2:2][CH2:3][N:4]1[C:8](=[O:14])[CH2:9][C:10]([CH3:12])=[N:7][CH2:6][CH2:5]1)(=[O:28])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

참가 물질

4

반응물 3

HCID 3893Lauric AcidHCID 7757Methyl acetoacetateHCID 8111Diethylenetriamine

생성물 1

HCID 705501004-lauramidoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

실험 절차

Into an apparatus similar to that in Example 1, were charged 103.1 g (1 mole) of diethylenetriamine and 116.1 g (1 mole) of methyl acetoacetate. At 140° to 150° C., 18 g of water and 32 g of methanol were distilled off. Then, with the addition of 200.3 g (1 mole) of lauric acid, the amide formation was effected at 200° to 210° C. and 18 g of water was distilled off, leaving behind 4-lauramidoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one.

후처리

  1. distillationAt 140° to 150° C., 18 g of water and 32 g of methanol were distilled off
  2. customwas effected at 200° to 210° C.
  3. distillation18 g of water was distilled off

출처 및 근거

ORD 기록
ord-d1de302304374230b80adac415af5331
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04346087

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