3-Chlorobenzoic Acid → Thionyl Chloride

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=O.[S:11]([Cl:14])([Cl:13])=[O:12].ClC1C=C(C=CC=1)C(Cl)=O.[NH2:25][C:26]([CH3:30])([CH3:29])[CH2:27]O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[O:7][CH2:27][C:26]([CH3:30])([CH3:29])[N:25]=2)[CH:8]=[CH:9][CH:10]=1.[S:11]([Cl:14])([Cl:13])=[O:12]

참가 물질

반응물 4

HCID 4473-Chlorobenzoic Acid

HCID 118072-Amino-2-methyl-1-propanol

HCID 24386Thionyl Chloride

HCID 69252Benzoyl chloride, 3-chloro-

생성물 2

HCID 24386Thionyl Chloride

HCID 10798476Oxazole, 2-(3-chlorophenyl)-4,5-dihydro-4,4-dimethyl-

실험 절차

2-(3-Chlorophenyl)-4,4-dimethyl-2-oxazoline was prepared from 3-chlorobenzoic acid by reaction with thionyl chloride to give 3-chlorobenzoylchloride, reaction of this acid chloride with 2-amino-2-methylpropanol to give the amide and cyclization of the amide with thionyl chloride followed by neutralization with dilute sodium hydroxide to give 2-(3-chlorophenyl)-4,4-dimethyl-2-oxazoline.