반응식
[CH:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][N:2]2[C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([NH2:19])[CH:15]=2)[N:10]=1.[F:20][C:21]([F:34])([F:33])[C:22]1[N:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30](O)=[O:31])=[CH:24][CH:23]=1.C(N(CC)CC)C.Cl.CN(C)CCCN=C=NCC>C(Cl)Cl.CN(C)C1C=CN=CC=1>[CH:1]12[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8]1)[CH2:3][N:2]2[C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([NH:19][C:30](=[O:31])[CH2:29][CH2:28][C:25]3[CH:26]=[N:27][C:22]([C:21]([F:20])([F:33])[F:34])=[CH:23][CH:24]=3)[CH:15]=2)[N:10]=1참가 물질
7
반응물 4
생성물 1
시약·촉매·용매 2
실험 절차
To a solution of the product of Step B (307 mg, 1.2 mmol), the product of Step E (404 mg, 1.2 mmol) and triethylamine (0.17 mL, 1.2 mmol) in 10 mL methylene chloride was added 4-dimethylaminopyridine (222 mg, 1.8 mmol) followed by 1-(3-dimethylaminopropyl)3-ethylcarbodiimide HCl (349 mg, 1.82 mmol). The resulting mixture was stirred at r.t. for 3 days. The solvent was removed under vacuum and residue was purified by preparative thin layer chromatography eluting with hexane/ethyl acetate/triethylamine (1:7:0.1) to afford the product, MS: m/z 455 (MH+), as an off-white solid.
후처리
- customThe solvent was removed under vacuum and residue
- customwas purified by preparative thin layer chromatography
- washeluting with hexane/ethyl acetate/triethylamine (1:7:0.1)
- customto afford the product, MS
출처 및 근거
- ORD 기록
- ord-0c1bf5a8f124408fb10931da146f70b7
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07084156B2
연결된 노트
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