Hydrochloric Acid → 3-Propoxynaphthalen-2-ylamine

HRID 68128

반응식

HRID 68128 반응식
[CH2:1]([O:4][C:5]1[C:6]([NH:15]C(=O)C)=[CH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:2][CH3:3].Cl.[OH-].[Na+]>C(O)C>[CH2:1]([O:4][C:5]1[C:6]([NH2:15])=[CH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:2][CH3:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58492454N-(3-propoxynaphthalen-2-yl)acetamide

생성물 1

HCID 212799043-Propoxynaphthalen-2-ylamine수율 100%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

N-(3-Propoxynaphthalen-2-yl)acetamide (2.5 g, 10.2 mmol) was dissolved in ethanol (10 ml). Concentrated hydrochloric acid (5.2 ml) was added thereto, and the resulting mixture was stirred for 4 hours while heating under reflux. The reaction mixture was cooled to room temperature, and a 5N aqueous sodium hydroxide solution (12.5 ml) was added thereto to adjust its pH to 11, followed by extraction using dichloromethane. The thus-obtained organic layer was concentrated to dryness under reduced pressure, and the residue was then purified using silica gel column chromatography (dichloromethane). The purified product was concentrated to dryness under reduced pressure, giving a white powder of 3-propoxynaphthalen-2-ylamine (2.05 g, yield: 100%).

후처리

  1. temperaturewhile heating
  2. temperatureunder reflux
  3. extractionfollowed by extraction
  4. concentrationThe thus-obtained organic layer was concentrated to dryness under reduced pressure
  5. customthe residue was then purified
  6. concentrationThe purified product was concentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-531862ea724b4025a6820c232ec276a5
출처 데이터셋
uspto-grants-2014_09
특허 번호
USRE045108E1

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