Triethylamine → 2-Bromo-1-(4-pyrimidin-2-ylpiperazin-1-yl)ethanone
반응식
[Br:1][CH2:2][C:3](Br)=[O:4].[N:6]1[CH:11]=[CH:10][CH:9]=[N:8][C:7]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(N(CC)CC)C>C1COCC1>[Br:1][CH2:2][C:3]([N:15]1[CH2:16][CH2:17][N:12]([C:7]2[N:6]=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:13][CH2:14]1)=[O:4]참가 물질
5
실험 절차
20.2 g bromacetylbromide was dropped to 16.5 g 1-pyrimidin-2-yl-piperazin and 10.2 g triethylamine in 250 mL THF. The reaction was stirred over night at RT and evaporated. The residue was extracted with DCM and water. The organic layer was evaporated and the residue was crystallized with petrolether and then purified by chromatography on silica gel (DCM/MeOH:95/5) to yield 36 mg of the desired compound.
후처리
- customevaporated
- extractionThe residue was extracted with DCM and water
- customThe organic layer was evaporated
- customthe residue was crystallized with petrolether
- custompurified by chromatography on silica gel (DCM/MeOH:95/5)
출처 및 근거
- ORD 기록
- ord-f971d6ac5dfa4b12a4f4c5f44ffe44c2
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08822464B2
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