Sodium Hydroxide → 1-(5-Chloropyrimidin-2-yl)piperidin-4-one

HRID 68793노트

반응식

HRID 68793 반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[OH-].[Na+]>Cl>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:17][CH2:16][C:11](=[O:12])[CH2:10][CH2:9]2)=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 682901798-(5-Chloropyrimidin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane

생성물 1

HCID 682896071-(5-Chloropyrimidin-2-yl)piperidin-4-one

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 8-(5-chloropyrimidin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane (4.2 g) in 6 M aqueous HCl (50 mL) is stirred at room temperature for 60 h. The solution is cooled in ice bath and 4 M aqueous NaOH solution (90 mL) is added in portions to make the solution strongly basic (pH˜14). The mixture is extracted with dichloromethane (2×200 mL) and the combined organic layers are dried over Na2SO4, filtered and concentrated to yield the title compound.

후처리

  1. temperatureThe solution is cooled in ice bath
  2. extractionThe mixture is extracted with dichloromethane (2×200 mL)
  3. dry with materialthe combined organic layers are dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d9c085edf15e415ebd1c4247be5d2954
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822471B2

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