Methylhydrazine → (E)-(2,4,6-trifluorophenyl)methylidenehydrazine

HRID 69140

반응식

HRID 69140 반응식
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([F:11])[C:3]=1[CH:4]=O.C[NH:13][NH2:14]>CCOCC>[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([F:11])[C:3]=1/[CH:4]=[N:13]/[NH2:14]

참가 물질

4

반응물 2

HCID 6061MethylhydrazineHCID 5218452,4,6-Trifluorobenzaldehyde

생성물 1

HCID 57917272(E)-(2,4,6-trifluorophenyl)methylidenehydrazine

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

2,4,6-Trifluoro-benzaldehyde (x) (4.5 g, 27.3 mmol) was dissolved in Et2O, methylhydrazine was added (1.43 mL, 27.3 mmol) and the RM was stirred overnight. The solvent was evaporated and the solid residue was suspended in a mixture of pentane and EtOAc to afford after filtration the title compound as a bright yellow crystalline solid (tR 4.95 min (conditions 3), MH+=198.1).

후처리

  1. customThe solvent was evaporated
  2. additionthe solid residue was suspended in a mixture of pentane and EtOAc
  3. customto afford
  4. filtrationafter filtration the title compound as a bright yellow crystalline solid (tR 4.95 min (conditions 3), MH+=198.1)

출처 및 근거

ORD 기록
ord-cd338e979c4d47d48408e78b4dc0922f
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822468B2

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