Acetic Anhydride → HCID 68991904, 화합물

HRID 69501

반응식

HRID 69501 반응식
[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][O:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[C:13](=[O:17])[CH2:12][CH2:11]2.[C:18]([O:21]C(=O)C)(=[O:20])[CH3:19].C([O-])(=O)C.[Pb+2].C([O-])(=O)C.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[O:17]=[C:13]1[C:14]2[C:10](=[CH:9][C:8]([O:7][CH2:6][C@H:2]3[CH2:3][CH2:4][CH2:5][O:1]3)=[CH:16][CH:15]=2)[CH2:11][CH:12]1[O:21][C:18](=[O:20])[CH3:19]

참가 물질

6

반응물 4

HCID 7918Acetic AnhydrideHCID 9317Lead diacetateHCID 10340Sodium CarbonateHCID 689893065-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one

생성물 1

HCID 68991904HCID 68991904, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

A mixture of 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one (1.25 g), acetic anhydride (3 mL), lead acetate (3.58 g) and acetic acid (3 mL) was stirred for 48 h at 100° C. After adding sodium carbonate solution it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 290.32 (C16H18O5); MS (ESI): 291 (M+H+).

후처리

  1. extractionwas extracted with ether
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. customThe residue was chromatographed on silica gel
  5. customIn this way the product was obtained with molecular weight 290.32 (C16H18O5)

출처 및 근거

ORD 기록
ord-c20828727c024484b3872a5e0f98f411
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822495B2

연결된 노트

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