4-Amino-6-chloro-2-methylthiopyrimidine → 6-chloro-N,N-di-BOC-2-(methyl-thio)pyrimidin-4-amine
반응식
[Cl:1][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]([NH2:10])[CH:3]=1.[O:11](C(OC(C)(C)C)=O)[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=O>CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]([N:10]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:11])[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:11])[CH:3]=1참가 물질
4
실험 절차
Method 24 was followed using 6-chloro-2-(methylthio)pyrimidin-4-amine (1.0 equiv.), BOC2O (2.0 equiv.), and DMAP (cat.) to afford 6-chloro-N,N-di-BOC-2-(methylthio)pyrimidin-4-amine in >95%. LCMS (m/z): 376.1 (MH+); LC Rt=4.9 min.
출처 및 근거
- ORD 기록
- ord-686d47d587ce4c5ebc3d4b2afe3d07dc
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08822497B2
반응 노트
불러오는 중…