Hydrochloric Acid → Picolinic acid

HRID 69966

반응식

HRID 69966 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([O-:9])=[O:8].[Li+].[OH-].Cl>C1COCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([OH:9])=[O:8]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 6920223Picolinate

생성물 1

HCID 1018Picolinic acid수율 98%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
60 °C

실험 절차

To a solution of methyl 3-amino-6-(2-fluoro-5-isopropylcabamoyl)phenyl)picolinate (1.0 equiv) in THF (0.5M), was added 1M LiOH (4.0 equiv). After stirring for 4 hours at 60° C., 1 N HCl (4.0 equiv.) was added and the THF was removed in vacuo. The resulting solid was filtered and rinsed with cold H2O (3×20 mL) to yield 3-amino-6-(2-fluoro-5-isopropylcabamoyl)phenyl)picolinic acid (98%). LCMS (m/z): 318.1 (MH+); LC Rt=2.4 min

후처리

  1. customthe THF was removed in vacuo
  2. filtrationThe resulting solid was filtered
  3. washrinsed with cold H2O (3×20 mL)

출처 및 근거

ORD 기록
ord-2bc4924df4b341d5b3a2a67aad801b75
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

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