Benzyl Chloride → 1,3,4-Thiadiazol-2-amine, 5-((phenylmethyl)thio)-

HRID 703826

반응식

HRID 703826 반응식
[NH2:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1.[OH-].[Na+].[CH2:10](Cl)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O.C(O)C>[NH2:1][C:2]1[S:3][C:4]([S:7][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:5][N:6]=1

참가 물질

6

반응물 3

HCID 7503Benzyl ChlorideHCID 14798Sodium HydroxideHCID 178509208HCID 178509208, 화합물

생성물 1

HCID 992851,3,4-Thiadiazol-2-amine, 5-((phenylmethyl)thio)-수율 94%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

반응 조건

온도
50 °C

실험 절차

In a mixture of 40 ml of water and 45 ml of ethanol, 21.1 g of 2-amino-5-mercapto-1,3,4-thiadiazole and 6.9 g of sodium hydroxide were dissolved. To this solution, 19.6 g of benzyl chloride was added, and the mixture was stirred at 50° C. for 1 hour. After cooling, water was added to the reaction mixture, the formed precipitate was separated by filtration and washed with water and an ethanol/n-hexane (1:1) mixture respectively. The thus treated precipitate was dried under reduced pressure, and thus 32.5 g of 2-amino-5-benzylthio-1,3,4-thiadiazole was obtained. m.p. 159°-161° C. Yield 94%.

후처리

  1. dissolutionwere dissolved
  2. temperatureAfter cooling
  3. customthe formed precipitate was separated by filtration
  4. washwashed with water
  5. customThe thus treated precipitate was dried under reduced pressure

출처 및 근거

ORD 기록
ord-384ab92d6add4c6d88eb0e2c8156c0e7
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985432

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