7a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine → (Hexahydro-1H-pyrrolizin-7A-YL)methanamine

HRID 704102

반응식

HRID 704102 반응식
[N+:1]([CH2:4][C:5]12[CH2:12][CH2:11][CH2:10][N:9]1[CH2:8][CH2:7][CH2:6]2)([O-])=O>[Ni].C(O)C>[NH2:1][CH2:4][C:5]12[CH2:12][CH2:11][CH2:10][N:9]1[CH2:8][CH2:7][CH2:6]2

참가 물질

4

반응물 1

HCID 104873597a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

생성물 1

HCID 10654304(Hexahydro-1H-pyrrolizin-7A-YL)methanamine수율 75%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

반응 조건

온도
20 °C

실험 절차

To a suspension of Raney nickel (300 mg) in 5.0 ml of ethanol, 7a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine (300 mg, 1.76 mmol, obtained in Example 1) was added and the resulting mixture was stirred for 1 hour at 20° C. under hydrogen atmosphere. The catalyst was filtered off, the filtrate was concentrated, and the resulting crude product was distilled in vacuo to afford 185 mg of the desired compound (Yield: 75%).

후처리

  1. additionwas added
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated
  4. distillationthe resulting crude product was distilled in vacuo

출처 및 근거

ORD 기록
ord-78612acd1ee047b1a1d64e394c2e893f
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985569

연결된 노트

불러오는 중…