Sodium Hydroxide → 3-Cyclohexyl-3-methylaminomethyloxetane

반응식

[CH:1]1([C:7]2([CH:11]=O)[CH2:10][O:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])(=O)C.[Na+].Cl.CN.[C:21]([BH3-])#[N:22].[Na+].[OH-].[Na+]>CO>[CH:1]1([C:7]2([CH2:11][NH:22][CH3:21])[CH2:10][O:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 5

HCID 14798Sodium Hydroxide

HCID 517045Sodium Acetate

HCID 5003444Sodium cyanoborohydride

HCID 6364545Methylamine hydrochloride

HCID 200755923-Cyclohexyl-3-formyloxetane

생성물 1

HCID 200755603-Cyclohexyl-3-methylaminomethyloxetane

시약·촉매·용매 1

실험 절차

3-Cyclohexyl-3-formyloxetane (1.7 g) was dissolved in methanol (10 ml) at 25° C. In succession, anhydrous sodium acetate (3.3 g), methylamine hydrochloride (3.4 g) and sodium cyanoborohydride (630 mg) were added, followed by a further volume of methanol (30 ml). The mixture was stirred overnight and then basified with sodium hydroxide solution (1M, 22 ml) to pH9. Ether extraction, washing and drying, followed by evaporation gave 3-cyclohexyl-3-methylaminomethyloxetane as a colourless oil.