Chloroacetyl chloride → 5-(2-chloroacetyl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

HRID 704626노트

반응식

HRID 704626 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[Cl:5][CH2:6][C:7](Cl)=[O:8].[CH3:10][C:11]1([CH3:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][C:12]1=[O:20]>C(=S)=S>[Cl:5][CH2:6][C:7]([C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:20])[C:11]2([CH3:21])[CH3:10])=[O:8]

참가 물질

5

반응물 3

HCID 6577Chloroacetyl chlorideHCID 3131003,3-Dimethyl-1,3-dihydro-indol-2-oneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 107523795-(2-chloroacetyl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-one수율 103.1%

시약·촉매·용매 1

HCID 6348Carbon Disulfide용매

실험 절차

To ice-cooled carbon disulfide (77 ml) were added anhydrous aluminum chloride (61.2 g) and chloroacetyl chloride (36.5 g), and then 2,3-dihydro-3,3-dimethylindol-2-one (24.6 g) was added thereto. The mixture was stirred for 10 minutes at ambient temperature and for 4 hours at 35° to 40° C. The solvent was removed by decantation and to the residue was added ice-water. The resulting crystal was collected, washed with water and dried to give 5-chloroacetyl-2,3-dihydro-3,3-dimethylindol-2-one (37.39 g).

후처리

  1. customThe solvent was removed by decantation and to the residue
  2. additionwas added ice-water
  3. customThe resulting crystal was collected
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-8cddfe6d01104f0ca37714b971946698
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04988698

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