(5-Chloro-6-methoxypyridin-2-yl)[4-(methylsulfanyl)phenyl]methanol → HCID 58452560, 화합물

HRID 70498

반응식

HRID 70498 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:10]([C:12]2[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=2)[OH:11])=[N:6][C:7]=1[O:8][CH3:9]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:10]([C:12]2[CH:13]=[CH:14][C:15]([S:18][CH3:19])=[CH:16][CH:17]=2)=[O:11])=[N:6][C:7]=1[O:8][CH3:9]

참가 물질

4

반응물 1

HCID 67396108(5-Chloro-6-methoxypyridin-2-yl)[4-(methylsulfanyl)phenyl]methanol

생성물 1

HCID 58452560HCID 58452560, 화합물수율 72.3%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

반응 조건

온도
65 °C

실험 절차

Manganese dioxide (8.34 g) was added to a solution of (5-chloro-6-methoxypyridin-2-yl)[4-(methylsulfanyl)phenyl]methanol (1.42 g) in chloroform (40 mL), and the mixture was stirred at 65° C. for one hour. The reaction solution was filtered through celite and the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1→1:1) to give the title compound as a yellow powder (1.02 g, 71%).

후처리

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1→1:1)

출처 및 근거

ORD 기록
ord-05aa97b3d97643d39956e86c0a758c43
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822503B2

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