O-Phenylenediamine → 2-Benzimidazolepropanol

HRID 7094

반응식

HRID 7094 반응식
[C:1]1([NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].Cl[CH2:10][CH2:11][CH2:12][C:13](O)=[O:14]>Cl>[NH:7]1[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[N:8]=[C:10]1[CH2:11][CH2:12][CH2:13][OH:14]

참가 물질

4

반응물 2

HCID 7243O-PhenylenediamineHCID 123004-Chlorobutanoic acid

생성물 1

HCID 754702-Benzimidazolepropanol수율 50%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of 1,2-Phenylenediamine (1.0 g, 12.0 mmol) and 4-chlorobutyric acid (1.5 mL, 15.17 mmol) were refluxed in 4N HCl (13 mL) for 16 hours under N2 to give the title compound as white solid (900 mg, 50%). 1H NMR (CD3OD) □ 2.04–2.08 (m, 2H), 2.97 (t, 2H, J=7.8 Hz), 5.64 (t, 2H, J=6.6 Hz), 7.15–7.21 (m, 2H), 7.47–7.49 (m, 2H); ES-MS m/z 177.1 (M+H).

출처 및 근거

ORD 기록
ord-e9d7394b8fab4a7884fe9288c6c7895d
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084155B2

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