Hydrazine hydrate (1:1) → 7-Bromo-2-hydrazinylquinoxaline

HRID 711364

반응식

HRID 711364 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](Cl)=[N:9]2)=[CH:4][CH:3]=1.O.[NH2:14][NH2:15]>C(O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]([NH:14][NH2:15])=[N:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 49132537-Bromo-2-chloroquinoxaline

생성물 1

HCID 52002657-Bromo-2-hydrazinylquinoxaline수율 87%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
78 °C

실험 절차

To the solution of 7-bromo-2-chloroquinoxaline (2 g, 8.2 mmol) in ethanol (20 mL) was added hydrazine hydrate (85%, 4.5 mL, 32.8 mmol). The mixture was heated to 78° C. for 2 h. After cooling to r.t., the precipitate was collected by filtration to afford 7-bromo-2-hydrazinylquinoxaline as white solid in 87% yield (1.7 g).

후처리

  1. temperatureAfter cooling to r.t.
  2. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-08c8fad82e5d4612abccac1ebd254385
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181264B2

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