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Hydrochloric Acid → 4-((3-Ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol

HRID 712409
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인쇄 미리보기

반응식

HRID 712409 반응식
C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[NH:17][C:18]1[CH:23]=[CH:22][C:21]([F:24])=[C:20]([C:25]#[CH:26])[CH:19]=1)(=O)C.[OH-].[Na+].Cl>CO>[C:25]([C:20]1[CH:19]=[C:18]([NH:17][C:8]2[C:7]3[C:12](=[CH:13][C:14]([O:15][CH3:16])=[C:5]([OH:4])[CH:6]=3)[N:11]=[CH:10][N:9]=2)[CH:23]=[CH:22][C:21]=1[F:24])#[CH:26]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 451403524-((3-Ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

생성물 1

HCID 451405424-((3-Ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol수율 83.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a suspension of 4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (5.29 g) and methanol (30 mL) was added 5 mol/L NaOH (10.00 mL) at room temperature. The reaction mixture was stirred at room temperature for 4 h, and was adjusted to pH 7 with 0.1 N HCl (aq). The mixture was filtered to give the title compound as a white solid (3.90 g, 83.69%).

후처리

  1. filtrationThe mixture was filtered

출처 및 근거

ORD 기록
ord-aca2f378499246cda9606bf79de2d73b
출처 데이터셋
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09181277B2

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