Hydrazine hydrate (1:1) → 3-Benzyl-3-azabicyclo(3.1.0)hexan-6-amine

HRID 712482노트

반응식

HRID 712482 반응식
[CH2:1]([N:8]1[CH2:13][CH:12]2[CH:10]([CH:11]2[N+:14]([O-])=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NN.O>[Ni].CO>[CH2:1]([N:8]1[CH2:13][CH:12]2[CH:10]([CH:11]2[NH2:14])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 215851823-Benzyl-6-nitro-3-azabicyclo[3.1.0]hexane

생성물 1

HCID 185069973-Benzyl-3-azabicyclo(3.1.0)hexan-6-amine수율 104.3%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

To a mixture of 3-benzyl-6-nitro-3-azabicyclo[3.1.0]hexane (4.00 g) and a catalytic amount of Raney nickel in MeOH was added slowly a solution of 98% H2NNH2—H2O (70 mL) at rt. The mixture was stirred for 5 h at room temperature and filtered. The filtrate was concentrated in vacuo to give the title compound as brown oil (3.60 g) and the crude product was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 204.3 (M+1).

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-a3338bfb92f0451ca9e679207868fa8a
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181277B2

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