Triphenylphosphine → 3-Bromo-5-(bromomethyl)pyridine
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8]O)[CH:5]=[N:6][CH:7]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1C(=O)N([Br:36])C(=O)C1>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([CH2:8][Br:36])[CH:3]=1참가 물질
5
실험 절차
(5-Bromo-pyridin-3-yl)-methanol (500 mg, 2.7 mmol) and triphenylphosphine (840 mg, 3.2 mmol) are dissolved in 12 mL of DCM and NBS (570 mg, 3.2 mmol) is added. The mixture is stirred for 4 hrs and then the reaction mixture is directly purified by flash column chromatography give 455 mg of 3-bromo-5-bromomethyl-pyridine.
후처리
- customthe reaction mixture is directly purified by flash column chromatography
출처 및 근거
- ORD 기록
- ord-f94edaf7e3f940ec97ec851b9df2b0a8
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09181272B2
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