3-Aminophenol → N2,N4-bis(3-hydroxyphenyl)-5-methyl-2,4-pyrimidinediamine

HRID 71378

반응식

HRID 71378 반응식
[OH:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=3)[C:12](F)=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.Cl[C:25]1N=C(Cl)C(C)=CN=1.OC1C=C(C=CC=1)N>>[OH:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=3)[C:12]([CH3:25])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 115683-AminophenolHCID 74508Pyrimidine, 2,4-dichloro-5-methyl-HCID 9904854R-112

생성물 1

HCID 22061056N2,N4-bis(3-hydroxyphenyl)-5-methyl-2,4-pyrimidinediamine

실험 절차

In a manner analogous to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, the reaction of 2,4-dichloro-5-methylpyrimidine with 3-hydroxyaniline gave N2,N4-bis(3-hydroxyphenyl)-5-methyl-2,4-pyrimidinediamine. LCMS: ret. time: 16.76 min.; purity: 100%, MS (m/e): 309 (MH+).

출처 및 근거

ORD 기록
ord-37227fae56924516ba21181be749560e
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822685B2

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