Hydrochloric Acid → HCID 71607581, 화합물

HRID 714493

반응식

HRID 714493 반응식
[CH:1]1[C:6]([C@@H:7]2[O:16][C:15]3[CH:14]=[C:13]([OH:17])[CH:12]=[C:11]([OH:18])[C:10]=3[CH2:9][C@@H:8]2[OH:19])=[CH:5][C:4]([OH:20])=[C:3]([OH:21])[CH:2]=1.[C:22](OC(=O)C)(=[O:24])[CH3:23].N1[CH:34]=[CH:33]C=CC=1.Cl.CN(C=[O:40])C>>[C:22]([O:21][C:3]1[CH:2]=[CH:1][C:6]([C@@H:7]2[C@H:8]([OH:19])[CH2:9][C:10]3[C:15](=[CH:14][C:13]([OH:17])=[CH:12][C:11]=3[OH:18])[O:16]2)=[CH:5][C:4]=1[O:20][C:33](=[O:40])[CH3:34])(=[O:24])[CH3:23]

참가 물질

6

반응물 5

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 6228DimethylformamideHCID 7918Acetic AnhydrideHCID 182232(+)-Epicatechin

생성물 1

HCID 71607581HCID 71607581, 화합물

실험 절차

To a stirred solution of (±) epicatechin 1 (0.10 gm, 0.34 mmol) in DMF, Acetic anhydride (0.11 ml, 0.10 mmol) and pyridine (0.08 ml, 0.10 mmol) was added at room temperature. After an additional stirring at this for 24 h, 2N HCl was added and extracted with ethyl acetate (2×50 ml). The combined organic layer was washed with brine and dried over sodium sulphate. The crude reaction mixture was purified using preparative HPLC to afford 4-((2R,3R)-3,5,7-trihydroxychroman-2-yl)-1,2-phenylene diacetate (0.004 gm) and 4-((2R,3R)-3,5,7-trihydroxychroman-2-yl)-1,2-phenylene diacetate (0.008 gm) as a white solid material.

후처리

  1. extractionextracted with ethyl acetate (2×50 ml)
  2. washThe combined organic layer was washed with brine
  3. dry with materialdried over sodium sulphate
  4. customThe crude reaction mixture
  5. customwas purified

출처 및 근거

ORD 기록
ord-48edf0783c39400e824884187be41586
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187448B2

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