Hydrochloric Acid → 2-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid

HRID 714524노트

반응식

HRID 714524 반응식
C([O:3][C:4](=[O:17])[CH2:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][C:7]=1[CH3:16])C.O.[Li+].[OH-].Cl>CO>[CH3:13][O:12][C:10]([C:9]1[CH:14]=[CH:15][C:6]([CH2:5][C:4]([OH:17])=[O:3])=[C:7]([CH3:16])[CH:8]=1)=[O:11]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 67365879Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate

생성물 1

HCID 575552242-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid수율 91.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate (366 mg) was suspended in MeOH(10 ml) and H2O (2 ml) and treated with LiOH (48 mg) over 3 days. After the reaction mixture was acidified with 1N HCl, the product was extracted with EtOAc. Evaporation and drying in vacuum afforded the desired product (295 mg).

후처리

  1. extractionthe product was extracted with EtOAc
  2. customEvaporation
  3. customdrying in vacuum

출처 및 근거

ORD 기록
ord-13c55a5b75694ab0bd94317153354e56
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187447B2

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