Methyl iodide → 2-(Methylthio)-1H-pyrimidin-4-one

HRID 714893

반응식

HRID 714893 반응식
[OH-].[Na+].[S:3]=[C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][NH:5]1.I[CH3:12]>C(O)(=O)C>[CH3:12][S:3][C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][N:5]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 1269845Thiouracil

생성물 1

HCID 798232-(Methylthio)-1H-pyrimidin-4-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To an aqueous solution (200 mL) of sodium hydroxide (23 g) were added 2-thioxo-2,3-dihydropyrimidin-4(1H)-one (37 g) and iodomethane (20 mL), and the mixture was stirred overnight at room temperature. To the reaction mixture was added acetic acid (17 mL), and the precipitate was collected by filtration, and washed with ice water. The residue was dried to give the title compound (28 g).

후처리

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with ice water
  3. customThe residue was dried

출처 및 근거

ORD 기록
ord-74fa7b4aec504bbdbd472f003f2699b9
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187453B2

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