Hydrochloric Acid → 1-(4-Bromophenyl)piperidin-4-one

반응식

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl.[OH-].[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]2)=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 121693418-(4-Bromophenyl)-1,4-dioxa-8-azaspiro[4.5]decane

생성물 1

HCID 246921481-(4-Bromophenyl)piperidin-4-one

반응 조건

온도: 50 °C

실험 절차

A mixture of 8-(4-bromophenyl)-1,4-dioxa-8-azaspiro[4.5]decane (1.02 g) and half concentrated hydrochloric acid is heated for 12 hours at 50° C., poured on ice and aqueous NaOH solution (4 M) is added until pH ˜7-8. Then the mixture is extracted with ethylacetate and the organic phase is washed with brine and dried (MgSO4). The solvents are evaporated in vacuo to give the title compound. LC (method 2): tR=0.96 min; Mass spectrum (ESI+): m/z=254 [M+H]+.