Dimethylformamide → HCID 86685017, 화합물

HRID 719052

반응식

HRID 719052 반응식
[C:1]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:6]=[CH:5][C:4]([CH:7]2[CH:26]=[C:25]3[C:10](=[CH:11][C:12]4[CH:13]=[C:14]5[C:22]([C:23]([CH3:28])([CH3:27])[C:24]=43)=[C:21]3[C:16]([CH:17]=[CH:18][CH:19]=[CH:20]3)=[N:15]5)[CH:9]=[CH:8]2)=[CH:3][CH:2]=1.CN(C=O)C.[Br:40]N1C(=O)CCC1=O>O>[C:1]1([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:6]=[CH:5][C:4]([CH:7]2[CH:26]=[C:25]3[C:10](=[C:11]([Br:40])[C:12]4[CH:13]=[C:14]5[C:22]([C:23]([CH3:27])([CH3:28])[C:24]=43)=[C:21]3[C:16]([CH:17]=[CH:18][CH:19]=[CH:20]3)=[N:15]5)[CH:9]=[CH:8]2)=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 67184N-bromobutanimideHCID 8668501610-(Biphenyl-4-yl)-12,12-dimethyl-10,12-dihydroindeno[2,1-b]carbazole

생성물 1

HCID 86685017HCID 86685017, 화합물수율 69.5%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

The resulting 10-(biphenyl-4-yl)-12,12-dimethyl-10,12-dihydroindeno[2,1-b]carbazole (42.5 g) and DMF (2.5 L) were added to a reaction vessel, and the mixture was heated up to 70° C. and dissolved. After cooled to a room temperature, N-bromo-succinimide (17.4 g) was added, and the mixture was stirred for 7 hours. Water (2.5 L) was added, and filtration was performed to obtain a white powder of 10-(biphenyl-4-yl)-7-bromo-12,12-dimethyl-10,12-dihydroindeno[2,1-b]carbazole (34.9 g; yield 69.5%).

후처리

  1. dissolutiondissolved
  2. temperatureAfter cooled to a room temperature
  3. filtrationfiltration

출처 및 근거

ORD 기록
ord-b49c04135a1f43248579297398a18285
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09196837B2

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