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Hydrochloric Acid → HCID 58737080, 화합물

HRID 720164
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인쇄 미리보기

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HRID 720164 반응식
C[O:2][C:3](=[O:38])[CH:4]([N:16]1[CH2:21][CH2:20][N:19]([C:22](=[O:33])[CH:23]([NH2:32])[CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH:18]([CH2:34][CH:35]=[CH2:36])[C:17]1=[O:37])[CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1.CO.[Li+].[OH-].Cl>C1COCC1.O>[CH2:34]([C@@H:18]1[N:19]([C:22](=[O:33])[C@H:23]([NH2:32])[CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH2:20][CH2:21][N:16]([C@@H:4]([CH2:5][C:6]2[CH:15]=[CH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH:7]=2)[C:3]([OH:38])=[O:2])[C:17]1=[O:37])[CH:35]=[CH2:36]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 695877082-{3-Allyl-4-[2-amino-3-(4-fluorophenyl)propionyl]-2-oxo-piperazin-1-yl}-3-naphthalen-2-yl-propionic acid methyl ester

생성물 1

HCID 58737080HCID 58737080, 화합물

시약·촉매·용매 2

HCID 962
Water
용매
HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-{3-allyl-4-[2-amino-3-(4-fluorophenyl)propionyl]-2-oxo-piperazin-1-yl}-3-naphthalen-2-yl-propionic acid methyl ester, 10, (168 mg, 0.324 mmol) in a mixture of THF (1 mL)/CH3OH (0.5 mL)/H2O (0.5 mL) is added LiOH (43 mg, 1.78 mmol). The reaction mixture is stirred for 3 hours, acidified with 1N HCl to pH 3 and extracted with EtOAc. The extract is dried over Na2SO4, filtered, concentrated and dried under high vacuum to afford the desired product in quantitative yield.

후처리

  1. extractionextracted with EtOAc
  2. dry with materialThe extract is dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-aa1109470b374efa80b879910f2aaf06
출처 데이터셋
uspto-grants-2006_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07132539B2

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