Sodium Bicarbonate → HCID 135828224, 화합물

HRID 720452노트

반응식

HRID 720452 반응식
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([SH:19])[N:3]=1.Br.Br[CH2:22][CH2:23][NH2:24].C([O-])(O)=O.[Na+]>CN(C=O)C.Cl>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:5]([C:17]#[N:18])=[C:4]([S:19][CH2:22][CH2:23][NH2:24])[N:3]=1

참가 물질

6

반응물 3

HCID 516892Sodium BicarbonateHCID 27742172-Bromoethylamine hydrobromideHCID 178510481HCID 178510481, 화합물

생성물 1

HCID 135828224HCID 135828224, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 6228Dimethylformamide용매

실험 절차

268 mg (1 mmol) of 2-amino-4-(4-hydroxyphenyl)-6-sulfanyl-3,5-pyridinedicarbonitrile, 105 mg (1 mmol) of 2-bromoethylamine hydrobromide and 168 mg (2 mmol) of NaHCO3 are stirred in 1 ml of DMF for 1 hour. The entire mixture is diluted with a few milliliters of 1N HCl. The crystals are filtered off with suction and dried under reduced pressure.

후처리

  1. filtrationThe crystals are filtered off with suction
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-2342196d5d1f465ba0c3943b3caf9250
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07135486B1

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