3,4-Diaminobenzonitrile → 2-Hydroxyquinoxaline-6-carbonitrile

HRID 72124

반응식

HRID 72124 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[NH2:10])[C:5]#[N:6].O.[C:12](O)(=O)[CH:13]=[O:14]>Cl>[O:14]=[C:13]1[CH:12]=[N:1][C:2]2[C:9](=[CH:8][CH:7]=[C:4]([C:5]#[N:6])[CH:3]=2)[NH:10]1

참가 물질

4

반응물 2

HCID 7372853,4-DiaminobenzonitrileHCID 15620607Glyoxylic acid, monohydrate

생성물 1

HCID 451217302-Hydroxyquinoxaline-6-carbonitrile

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

To a stirred solution of 3,4-diaminobenzonitrile (5.00 g, 37.6 mmol) in 5% aq HCl (20 mL) was added glyoxilic acid monohydrate (4.32 g, 46.9 mmol). The mixture was stirred overnight at rt and filtered. The filter cake was washed with water and MeOH to afford 2-oxo-1,2-dihydroquinoxaline-6-carbonitrile as a grey solid which was used directly in the next step.

후처리

  1. filtrationfiltered
  2. washThe filter cake was washed with water and MeOH

출처 및 근거

ORD 기록
ord-f4d6d8765b134ec98904a66135422cd8
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828985B2

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